1/16 FINALE| 16.02/22.02 | FC Porto - Manchester City FC | 1:2 (1:0) | 0:4 (0:1) |
| 16.02/23.02 | AFC Ajax - Manchester United FC | 0:2 (0:0) | 2:1(1:1) |
| 16.02/23.02 | Lokomotiv Mosca - Athletic Club de Bilbao | 2:1 (0:1) | 0:1 (0:0) |
| 16.02/23.02 | FC Salzburg - Metalist Charkov | 0:4 (0:3) | 1:4 (0:1) |
| 16.02/23.02 | Stoke City FC - València CF | 0:1 (0:1) | 0:1 (0:1) |
| 14.02/23.02 | Rubin Kazan - Olympiakós SFP Pireo | 0:1 (0:0) | 0:1 (0:1) |
| 16.02/23.02 | AZ Alkmaar - RSC Anderlecht | 1:0 (0:0) | 1:0 (0:0) |
| 16.02/23.02 | SS Lazio - Club Atlético de Madrid | 1:3 (1:2) | 0:1 (0:0) |
| 16.02/23.02 | Steaua Bucaresti - FC Twente | 0:1 (0:0) | 0:1 (0:1) |
| 16.02/23.02 | FC Viktoria Plzeň - FC Schalke 04 | 1:1 (1:0) | 1:3 d.t.s. (0:1) |
| 16.02/23.02 | Wisła Cracovia - Royal Standard de Liège | 1:1 (0:1) | 0:0 (0:0) |
| 14.02/23.02 | SC Braga - Beşiktaş JK | 0:2 (0:1) | 1:0 (1:0) |
| 16.02/23.02 | Udinese Calcio - PAÓK | 0:0 (0:0) | 3:0 (2:0) |
| 16.02/23.02 | Trabzonspor Kulübü - PSV Eindhoven | 1:2 (1:2) | 1:4 (1:3) |
| 16.02/23.02 | Hannover 96 - Club Brugge KV | 2:1 (0:0) | 1:0 (1:0) |
| 16.02/23.02 | Legia Varsavia - Sporting Lisabon | 2:2 (1:0) | 0:1 (0:0) |
1/8 FINALE| 08.03/15.03 | Metalist Charkov - Olympiakós SFP | 0:1 (0:0) | 2:1 (0:1) |
| 08.03/15.03 | Sporting Lisabon - Manchester City FC | 1:0 (0:0) | 2:3 (2:0) |
| 08.03/15.03 | FC Twente - FC Schalke 04 | 1:0 (0:0) | 1:4 (1:1) |
| 08.03/15.03 | Royal Standard de Liège - Hannover 96 | 2:2 (2:1) | 0:4 (0:2) |
| 08.03/15.03 | València CF - PSV Eindhoven | 4:2 (3:0) | 1:1 (0:0) |
| 08.03/15.03 | AZ Alkmaar - Udinese Calcio | 2:0 (0:0) | 1:2 (1:2) |
| 08.03/15.03 | Club Atlético de Madrid - Beşiktaş JK | 3:1 (3:0) | 3:0 (1:0) |
| 08.03/15.03 | Manchester United FC - Athletic Club de Bilbao | 2:3 (1:1) | 1:2 (0:1) |
1/4 FINALE| 29.03/05.04 | AZ Alkmaar - València CF | 2:1 (1:0) | 0:4 (0:2) |
| 29.03/05.04 | FC Schalke 04 - Athletic Club de Bilbao | 2:4 (1:1) | 2:2 (1:1) |
| 29.03/05.04 | Sporting Lisabon - Metalist Charkov | 2:1 (0:0) | 1:1 (1:0) |
| 29.03/05.04 | Club Atlético de Madrid - Hannover 96 | 2:1 (1:1) | 2:1 (0:0) |
1/2 FINALE| 19.04/26.04 | Club Atlético de Madrid - València CF | 4:2 (1:1) | 1:0 (0:0) |
| 19.04/26.04 | Sporting Lisabon - Athletic Club de Bilbao | 2:1 (0:0) | 1:3 (1:2) |
| 09.05 | Club Atlético de Madrid - Athletic Club de Bilbao | 3:0 (2:0) |
7', 34' Falcao, 85' Diego
